Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions.
Boer DE, Mirzaian M, Ferraz MJ, Zwiers KC, Baks MV, Hazeu MD, Ottenhoff R, Marques ARA, Meijer R, Roos JCP, Cox TM, Boot RG, Pannu N, Overkleeft HS, Artola M, Aerts JM.
Boer DE, et al.
J Lipid Res. 2021;62:100018. doi: 10.1194/jlr.RA120001043. Epub 2021 Jan 6.
J Lipid Res. 2021.
PMID: 33361282
Free PMC article.
Here we show that recombinant human GBA also cleaves beta-xylosides and transxylosylates cholesterol. The xylosyl-cholesterol formed acts as an acceptor for the subsequent formation of di-xylosyl-cholesterol. Common mutant forms of GBA from patients with Gaucher dis …
Here we show that recombinant human GBA also cleaves beta-xylosides and transxylosylates cholesterol. The xylosyl-cholesterol formed …